{"id":36,"date":"2019-10-15T09:53:14","date_gmt":"2019-10-15T06:53:14","guid":{"rendered":"http:\/\/www.oguzkayiran.com\/?p=36"},"modified":"2019-11-22T16:12:32","modified_gmt":"2019-11-22T13:12:32","slug":"botox","status":"publish","type":"post","link":"https:\/\/www.oguzkayiran.com\/de\/botox\/","title":{"rendered":"Botox"},"content":{"rendered":"<p>Botulinum n\u00f6rotoksini (BTX) t\u0131bbi ama\u00e7l\u0131 uygulanan ilk mikrobiyal proteindir.<\/p>\n<p>BTX ancak 1989 y\u0131l\u0131nda strabismus ve blefarospazm ic\u0327in, 2000 y\u0131l\u0131nda servikal distoni tedavisi ic\u0327in FDA onay\u0131 alabilmis\u0327tir. Glabellar (ka\u015f aras\u0131) c\u0327izgilerin tedavisindeki etkisi nedeni ile de 2002 y\u0131l\u0131nda FDA onay\u0131 alm\u0131s\u0327t\u0131r.<\/p>\n<p>BTX\u2019in 7 farkl\u0131 serotipi (A, B, C, D, E, F, G) vard\u0131r. Gu\u0308nu\u0308mu\u0308zde tedavi amac\u0131yla yaln\u0131z A ve B tipleri kullan\u0131lmaktad\u0131r. Ticari olarak u\u0308retilmis\u0327 ve kullan\u0131m\u0131 olan Botox\u00ae ve Dysport\u00ae serotip A\u2019dan, Myobloc\u00ae ise serotip B\u2019den yap\u0131lm\u0131s\u0327t\u0131r.<\/p>\n<p>Myobloc\u00ae: Servikal distonide FDA onay\u0131 vard\u0131r. Tip A\u2019ya antikor gelis\u0327tirmis\u0327 hastalar ile yap\u0131lm\u0131s\u0327 c\u0327al\u0131s\u0327malar bildirilmis\u0327tir. Kozmetik kullan\u0131mda onay\u0131 yoktur.<\/p>\n<p>Xeomin\u00ae : Yeni piyasaya sunulan ve 150 kDa ag\u0306\u0131rl\u0131g\u0306\u0131nda nontoksin proteinden u\u0308retilen ve sadece Almanya\u2019da bulunan bir u\u0308ru\u0308ndu\u0308r.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>ETK\u0130LER\u0130 VE UYGULAMA ALANLARI<\/strong><\/p>\n<p>BTX, ge\u00e7ici ama irreversibl kas felci yaparak etki etmektedir. Etkisi 2-3 g\u00fcnde ba\u015flay\u0131p, 7-10 g\u00fcnde maksimum etkinli\u011fe ula\u015fmaktad\u0131r ve ortalama 4-6 ay kal\u0131c\u0131l\u0131k bildirilmektedir. Pratik olarak ka\u015f aras\u0131, al\u0131n, ka\u015f kald\u0131rma, kaz ayaklar\u0131, boyun bantlar\u0131, dudak \u00e7izgilenmeleri, \u00e7ene ve y\u00fcz \u015fekillendirme i\u00e7in masseter kas\u0131 i\u00e7ine ve el-ayak-koltukalt\u0131 terleme tedavisi gibi kozmetik uygulama alanlar\u0131, strabismus, blefarospazm, serebral palsi, migren ve trismus vb gibi t\u0131bbi uygulama alanlar\u0131 mevcuttur.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>KONTRENDI\u0307KASYONLARI <\/strong><\/p>\n<p>BTX baz\u0131 durumlarda kullan\u0131lamamaktad\u0131r.<\/p>\n<ul>\n<li>Daha o\u0308nce var olan kas hastal\u0131klar\u0131 [miyastenia gravis ve Eaton-Lambert sendromu gibi no\u0308romusku\u0308ler hastal\u0131klar, Amiyotrofik lateral skleroz (ALS) gibi motor no\u0308ron hastal\u0131klar\u0131 ve periferik motor no\u0308ropatik hastal\u0131klar]<\/li>\n<li>Enjeksiyon bo\u0308lgesinde enfeksiyon<\/li>\n<li>Formu\u0308lasyon ic\u0327erig\u0306indeki herhangi bir maddeye kars\u0327\u0131 bilinen bir hipersensitivite<\/li>\n<li>Aminoglikozid antibiyotikler ya da dig\u0306er no\u0308romusku\u0308ler gec\u0327is\u0327i etkileyen ilac\u0327lar (ku\u0308rar gibi depolarizan olmayan bloko\u0308rler, kalsiyum kanal blokerleri, kinidin, magnezyum su\u0308lfat, su\u0308ksinil kolin) alan hastalar<\/li>\n<\/ul>\n<p>Anne su\u0308tu\u0308ne gec\u0327ip gec\u0327medig\u0306i de tam olarak bilinmedig\u0306inden gebelik ve laktasyonda kullan\u0131lmas\u0131 o\u0308nerilmemektedir.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>UYGULAMA SONRASI KASLARIN DURUMU <\/strong><\/p>\n<p>U\u0308ru\u0308n uyguland\u0131ktan sonra yaklas\u0327\u0131k 2.5-3 cm\u2019lik bir alana dag\u0306\u0131lmaktad\u0131r. I\u0307ki ila bes\u0327 kez estetik nedenlerle BTX yapt\u0131rm\u0131s\u0327 hastalardan is\u0327lem sonras\u0131 al\u0131nan biyopsi materyalinin histolojik incelenmesinde dejenerasyon ya da atrofi saptanmam\u0131s\u0327t\u0131r.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>YAN ETK\u0130LER<\/strong><\/p>\n<p>Yan etkiler \u00e7ok ender de olsa bildirilmi\u015ftir (Gribe benzer sendrom, kas ag\u0306r\u0131lar\u0131-gu\u0308c\u0327su\u0308zlu\u0308g\u0306u\u0308, bas\u0327 ag\u0306r\u0131s\u0131, bas\u0327 do\u0308nmesi, ates\u0327-titreme, hipertansiyon, diyare, abdominal ag\u0306r\u0131).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Botulinum n\u00f6rotoksini (BTX) t\u0131bbi ama\u00e7l\u0131 uygulanan ilk mikrobiyal proteindir. BTX ancak 1989 y\u0131l\u0131nda strabismus ve blefarospazm ic\u0327in, 2000 y\u0131l\u0131nda servikal distoni tedavisi ic\u0327in FDA onay\u0131 alabilmis\u0327tir. Glabellar (ka\u015f aras\u0131) c\u0327izgilerin tedavisindeki etkisi nedeni ile de 2002 y\u0131l\u0131nda FDA onay\u0131 alm\u0131s\u0327t\u0131r. BTX\u2019in 7 farkl\u0131 serotipi (A, B, C, D, E, F, G) vard\u0131r. Gu\u0308nu\u0308mu\u0308zde tedavi amac\u0131yla [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":376,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,24],"tags":[],"class_list":["post-36","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-asthetische-anwendunge","category-erkeklere-ozel"],"_links":{"self":[{"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/posts\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/comments?post=36"}],"version-history":[{"count":3,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/posts\/36\/revisions"}],"predecessor-version":[{"id":377,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/posts\/36\/revisions\/377"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/media\/376"}],"wp:attachment":[{"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/media?parent=36"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/categories?post=36"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.oguzkayiran.com\/de\/wp-json\/wp\/v2\/tags?post=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}